USAP-DC

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Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (\u0192H), adrenaline (5 nmol kg-1 bolus intra-arterial injection) did not significantly increase cardiac output (Q\u0307) in vivo because it elicited a large decrease in vascular conductance (Gsys). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg-1) generated a large increase in Q\u0307 by increasing Gsys, a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q\u0307 in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart. ", "citation": "O'Brien, K., Axelsson, M., Egginton, S., Farrell, A., & Joyce, M. 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Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus Data DOI: https://doi.org/10.15784/601409 Cite as O'Brien, K., Axelsson, M., Egginton, S., Farrell, A., & Joyce, M. (2020) "Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus" U.S. Antarctic Program (USAP) Data Center. doi: https://doi.org/10.15784/601409. AMD - DIF Record(s) USAP-1341602_1 Abstract Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the roles for adrenaline and adenosine, two well-established cardio- and vasoactive molecules, in regulating the cardiovascular system of the blackfin icefish, Chaenocephalus aceratus. Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (ƒH), adrenaline (5 nmol kg-1 bolus intra-arterial injection) did not significantly increase cardiac output (Q̇) in vivo because it elicited a large decrease in vascular conductance (Gsys). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg-1) generated a large increase in Q̇ by increasing Gsys, a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q̇ in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart. Creator(s): O'Brien, Kristin; Joyce, Michael; Axelsson, Michael; Farrell, Anthony; Egginton, Stuart Date Created: 2020-12-18 Repository: USAP-DC (current) License: Creative Commons Attribution Only v4.0 Generic [CC BY 4.0] Temporal Extent(s) Start: 2014-09-01 - End: 2019-08-31 Award(s) NSF 1341602 NSF 1341663 Version: 1 Related Project(s) Collaborative Research: The Physiological and Biochemical Underpinnings of Thermal Tolerance in Antarctic Notothenioid Fishes References William Joyce, Stuart Egginton, Anthony P Farrell , Michael Axelsson (2019) Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish: Insight into central and peripheral determinants of cardiac output. Comp Biochem Physiol A Mol Integr Physiol 230:28-38. (doi:10.1016/j.cbpa.2018.12.012 ) Keywords Antarctic Peninsula Antarctica